Hielscher UIP400MTP Multiwell Plate Sonicator
The Hielscher UIP400MTP Multiwell Plate Sonicator is a powerful ultrasonic device that is primarily used in biotechnology and pharmaceutical laboratories for effective cell disruption, precise nucleic acid extraction and uniform chromatin fragmentation. This solution is specifically designed to meet high throughput requirements while delivering consistently reproducible results. Compared to other ultrasonic devices available on the market, this model impresses in both small and large laboratory settings with special requirements. Thanks to its customisable parameters, robust construction and integrated circulation technology for temperature control, it is the ideal choice for demanding research and analysis processes.
Versatile ultrasonic technology for different samples
The device enables high-precision control of the required ultrasonic parameters such as amplitude, pulse duration and temperature. This ensures optimal adjustment to the respective application or the sample material to be homogenised. Particularly in cell lysis processes - whether for mammalian or plant cells, bacteria or yeasts - large sample quantities can be broken down in a very short time by parallel processing of multiwell plates. The system also impresses with clearly defined and reproducible results when extracting or fragmenting DNA, RNA or proteins. Those who value process stability will also benefit from the robust design and CE conformity.
Key technical features
- 400 watts of ultrasonic power at 20 kHz
- Housing dimensions of approximately 30 × 43 × 36 cm with a total weight of around 30 kg
- Widely applicable with microtitre plates from 1 to 1536 wells
- Adjustable parameters for amplitude, pulse duration, cycles and temperature
- Integrated circulation pump for precise cooling and temperature control
- Acrylic glass cover for clean, protected operation
- Certifications such as CE for reliable safety and quality guidelines
These concentrated core factors ensure that users can precisely coordinate all process steps without the need for time-consuming adjustments or proprietary consumables. The greater flexibility facilitates integration into existing workflows and minimises ongoing operating costs. Even sensitive samples such as FFPE tissue (formalin-fixed, paraffin-embedded samples) can be processed gently without compromising DNA or RNA integrity.
Excellent integration into automated laboratory systems
To meet the requirements of laboratory-wide automation, the system is equipped with an interface that allows external control and monitoring. This allows complete process chains to be flexibly mapped, for example in pharmaceutical R&D departments, biotech laboratories or high-tech diagnostic centres. The theory proves to be particularly user-friendly in practice, especially when it comes to integration into robotic systems or automated pipetting stations. Precise process data acquisition ensures complete documentation, which makes workflows increasingly efficient.
Specific applications
- Cell lysis in large-scale screening projects: In studies with numerous samples, the parallel processing of multiwell plates saves time and ensures consistent results.
- Nucleic acid extractions in 96-well format: Individually adjustable ultrasonic intensity minimises the risk of sample damage while achieving effective fragmentation. - Chromatin fragmentation for epigenetic studies: Precise control of intensity enables targeted fragmentation to specific DNA lengths, which is essential for ChIP assays or other epigenetic analyses.
- Protein extraction and solubilisation: Suspension cultures benefit from short sonication times, easy temperature control and reliable disruption of cell structures.
FAQs
How is the temperature controlled?
An integrated circulation pump allows the device to maintain the temperature of the samples being processed at a desired level. This technology provides effective cooling even during longer sonication cycles.
Can the system be used for various multiwell plates?
Yes, thanks to its universal design, it can be used with all common formats - from classic 96-well plates to high-density 1536-well variants.
Can the device be automated?
An existing interface enables control and monitoring by external systems. This makes it easy to integrate into robotic platforms or data acquisition systems to create continuous workflows.
Is uniform energy distribution guaranteed in all wells?
The design ensures homogeneous vibration transmission across the entire plate. Individually adjustable ultrasound parameters ensure consistent sonication in all wells.
For which sample types is the ultrasonic system particularly suitable?
It is primarily designed for cell lysis, DNA and RNA extractions, chromatin fragmentation and protein processing. However, the settings can be flexibly adjusted to support other biochemical and molecular biological processes as well.
Conclusion
Thanks to its robust construction and precise control of essential ultrasonic parameters, this powerful system meets the highest demands in research and development. Compatibility with various multiwell formats, coupled with integrated temperature control, creates new opportunities for fast and efficient sample processing in laboratories. Users not only save time, but also gain confidence in their results - whether in cell lysis, nucleic acid purification or chromatin fragmentation. Those who value process stability and reproducible results will find this ultrasonic system to be a well-designed and reliable solution that can be easily integrated into existing laboratory configurations.
